Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase (3EBG, 3EBH, 3EBI)

Authors:
Buckle A.M., Porter C.J., Whisstock J.C., McGowan, S.

Abstract:

This experiment holds 3EBG, 3EBH and 3EBI.

PDB id(s): 3EBG, 3EBH, 3EBI

Citations:
http://www.rcsb.org/pdb/explore/explore.do?structureId=3EBI
http://www.rcsb.org/pdb/explore/explore.do?structureId=3EBH
http://www.rcsb.org/pdb/explore/explore.do?structureId=3EBG
http://www.ncbi.nlm.nih.gov/pubmed/19196988?dopt=Abstract

Persistent Handle: 102.100.100/3

Institution: Monash University

Dataset Information:

  • Datasets: 4
  • Files: 1117

Experiment Last Updated: 30th April 2010 10:32

DATASET 1
Dataset Description: Structure of the M1 Alanylaminopeptidase from malaria
Dataset Metadata: [Hide]
  • Resolution Limit: 2.1 Å
  • Diffractometer Type: Rotating Anode
  • X-Ray Source: RIGAKU RAXIS IV
  • Crystal Name: PlyB_D1
Data Files (275): [Show]
DATASET 2
Dataset Description: Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog
Dataset Metadata: [Hide]
  • Resolution Limit: 2.0 Å
  • Diffractometer Type: Rotating Anode
  • X-Ray Source: RIGAKU RAXIS IV
  • Crystal Name: PlyB_D1
Data Files (363): [Show]
DATASET 3
Dataset Description: Structure of the M1 Alanylaminopeptidase from malaria complexed with bestatin
Dataset Metadata: [Hide]
  • Resolution Limit: 1.65 Å
  • Diffractometer Type: Synchrotron
  • X-Ray Source: RIGAKU RAXIS IV
  • Crystal Name: PlyB_D1
Data Files (470): [Show]
DATASET 4
Dataset Description: M1_3EBG Structure of the M1 Alanylaminopeptidase from malaria
9_refmac5_final.log Final refinement log file. Refmac v5.2.0019
80_scala.log Processing log file from SCALA
p212121_scala1.mtz Processed data

M1_BES_3EBH Structure of the M1 Alanylaminopeptidase from malaria complexed with bestatin
4_refmac5_finalBES.log Final refinement log file. Refmac v5.2.0019
41_scala.log Processing log file from SCALA
xtal8c_p212121_scala1.mtz Processed data

M1_Co4_3EBI Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog
.osc files Raw image files. In-house Rotating Anode (Rigaku RAxis IV)
12_refmac5_final Co4.log Final refinement log file. Refmac v5.2.0019
45_scala.log Processing log file from SCALA
3EBIco4_p212121_scala1.mtz Processed data
Data Files (9): [Show]